J Emerg Med. 2019 Oct;57(4):587-588

Ketamine: Safe Until It's Not - A Terrifying Trip to the K-Hole.

Simon E

On a daily basis we, as emergency medicine providers, discuss drugs and their side effect profiles. We often survey our colleagues regarding rare reported phenomena that have not been previously encountered. In my short emergency medicine career, I've heard the praises of ketamine thousands of times over: “Ketamine is safe and effective.” “You can never give too much ketamine.” “You can theoretically get an emergence reaction, but I haven't seen it.” I will be the first to admit that I used ketamine for nearly every procedural sedation that I performed—until my little adventure to the K-hole.