There is an abundance of evidence that limb tourniquets have a positive effect on clinical outcomes, and the early application leads to the best results. Likewise, the research and studies done on hemostatic dressings and pressure bandage application are significant, and these both reach the level of high supporting evidence.

The junctional hemorrhage measure evidence is robust, but not quite as extensive as the limb tourniquet and wound packing evidence; nevertheless, there is a moderate to high level of support for those strategies.

The evidence behind injectable hemostatic agents is less robust, with most of the studies being animal-based and the human studies focused on case reports and subject matter expert opinions, which is why it is rated as low to moderate.

And although the wound closure device also has subject matter expert opinion, there are some retrospective studies that help provide a moderate level of supporting evidence.