Drug interactions include; probenecid decrease renal excretion.

The Onset/Peak/Duration for ertapenem is 30 sec-5 min/30 min-2 hr/24hr.

Ertapenem should not be mixed or co-infused with other medications to prevent crystallization and should not be mixed with diluents containing dextrose. It may be administered intramuscularly (IM) if needed. However, in that case it should be reconstituted with 3.2 mL of 1.0% lidocaine HCl (without epinephrine), instead of saline or bacteriostatic water.

Ertapenem became the parenteral antibiotic of choice based on its once-a-day dosing, its excellent broad-spectrum coverage, and its good safety profile.