Drug interactions include; iron, zinc, antacids, aluminum, magnesium, calcium, and sucralfate decrease absorption, atenolol, cisapride, erythromycin, antipsychotics, TCAs, quinidine, procainamide, amiodarone, sotalol may prolong QTc interval, may cause false positive on opiate screening tests.

The Onset/Peak/Duration for moxifloxacin is 1 hr/2 hr/20-24 hr.

The casualty should use their own medication, unless for some reason they no longer have access to their own CWMP.

Moxifloxacin has excellent intraocular penetration when taken systemically (as opposed to other antibiotics which require intravitreal injection) and is effective for most gram-positive and gram-negative bacteria that might cause post-injury endophthalmitis, which is another advantage when dealing with eye injuries.

Other fluoroquinolones may occasionally be found at forward locations, but moxifloxacin is the quinolone of choice at this point. Gatifloxacin was previously recommended, but was later reported to cause disorders of glucose metabolism and was subsequently replaced. And levofloxacin has been considered based on its effectiveness against gram-negative bacteria; but with some recent increase in drug-resistant strains, no change has been recommended.

Individuals with known medication allergies to the fluoroquinolone class of medications should be identified, as they may require a different class of antibiotics. Examples of this include the two just mentioned, gatifloxacin and levofloxacin, as well as ciprofloxacin. You should screen your troops for medication allergies prior to deploying, when you provide them with Combat Wound Medication Packs, and be aware of any allergies that members may have to medications recommended in the TCCC Guidelines. If an individual should not take moxifloxacin, consult with your medical officer to determine the appropriate substitute antibiotic.