The use of blood products for these patients is a complex issue involving the proper use of limited resources in theater and the paucity of evidence-based recommendations on this topic. If the patient responds hemodynamically to the previous interventions and appears stable after the initial insult, a reasonably aggressive approach should be taken to correct coagulopathy rapidly and transfuse PRBCs to a level sufficient to optimize oxygen delivery to tissue and organs. There is little to support optimal hemoglobin in this population, but in general critically ill populations, a target above at least 7g/dL has been recommended.30 In this patient population, however, goal hemoglobin of 10g/dl has been set for this protocol. (See Appendix A.) Other blood products are used as per standard ICU practice to correct pre-existing traumatic coagulopathy or disseminated intravascular coagulation generated by the release of tissue factor from necrotic brain tissue. An International Normalized Ration (INR)<1.5 and platelet count >50,000 should be considered until evacuation occurs.31