Canine Freeze Dried Plasma (cFDP) can be used in lieu of FFP for any of the above-mentioned indications cited for FFP. In addition, since cFDP can be reconstituted quickly (does not require a thawing process), it is possible to start a transfusion more rapidly as compared to FFP. When available, strongly consider cFDP as a resuscitation product at the point of injury, en route to Role 2 or 3 care and/or until canine WB becomes available. cFDP replaces effective circulating volume without diluting coagulation factors or substantially reducing oncotic pressure. In this way, cFDP’s most beneficial role on the battlefield is to serve as bridge to resuscitation with canine WB. Evidence supports that cFDP is biologically equivalent to FFP in terms of coagulation factor activity, biochemical profile and clot forming ability (Edwards – unpublished data).

 

HANDLING/ STORAGE

 

RECONSTITUTION

Follow the manufacturer’s directions in the reconstitution of cFDP. In general, sterile water for injection (amount specified by the manufacturer) is aseptically added through either an inserted port or the designated port provided on the bag of cFDP. Gently manually mix the bag until the product completely dissolves (approximately 5 minutes). Once reconstituted, either transfuse within 4 hours of reconstitution or refrigerate for up to 28 days.

 

DOSAGE

 

ADMINISTRATION

 

Note: Although an in-line filter is recommended to reduce clots or other impurities from the transfused product, the lack of a blood filter does not preclude the administration of FDP if the transfusion is clinically necessary.

 

TRANSFUSION MONITORING AND REASSESSMENT