- The sensors in the i-STAT cartridges are standardized against plasma methods used by major laboratory systems. The i-STAT is programed with CLEW software, the coefficients of which are determined by comparing the i-STAT results to this standardization process. Due to possible changes in the manufacturing process, the CLEW software requires recalibration to avoid drift from the lab values produced by the major laboratory systems. This is why software updates are mandated twice a year.
- The i-STAT analyzer will not function with expired software. A warning will appear on the screen 15 days before the software expires.
- The i-STAT can be updated using a desktop computer or another i-STAT with current software (Appendix D).
  - This method may be problematic for deployed personnel due to regulations preventing attachment of devices to government computers.
  - If this method is approved by command, the software can be downloaded from the internet.
  - Navigate directly to http://www.abbottpointofcare.com/Customer-Info-Center.aspx.
  - Registration using a military email address will be required.
- The i-STAT can be updated using a second i-STAT with current software. This method may be easier in the deployed setting since it avoids the issue of having to attach a device to a government computer and does not require the internet. The second device may be obtained from another CCATT or an MTF. A step-by-step instruction set is presented in Appendix D.
- It is recommended that deployed personnel coordinate with a nearby MTF or contact a servicing biomedical maintenance shop as needed for assistance with software updates.