The following are MACE risk factors:

- Hypertension
- Hypercholesterolemia
- Diabetes mellitus
- Obesity (body max index > 30 kg/m2)
- Smoking (current, or smoking cessation < 1 month)
- Positive family history for coronary artery disease
- Atherosclerotic disease
- Prior MI, PCI, CABG, cerebrovascular accident/transient ischaemic attack or peripheral artery disease

The following are the score levels for MACE:

- 0 – 3: low risk; 1.7% found to have MACE
- 4 – 6: moderate risk; 16.6% found to have MACE
- 7 – 10: high risk; 50.1% found to have MACE

Sources:

1. Backus BE, Six AJ, Kelder JC, et al. A prospective validation of the HEART score for chest pain patients at the emergency department. Int J Cardiol 2013;168:2153-8.
2. Backus BE, Six AJ, Kelder JC, et al. Chest pain in the emergency room: a multicenter validation of the HEART Score. Crit Pathw Cardiol 2010;9:164-9.
3. Six AJ, Backus BE, Kelder JC. Chest pain in the emergency room: value of the HEART score. Neth Heart J 2008;16:191-6.