1. Eastridge BJ, Mabry RL, Seguin P, et al. Death on the battlefield (2001-2011): Implications for the future of combat casualty care. J Trauma Acute Care Surg, 2012. 73(6 Suppl 5): p. S431-7.
2. Shackelford SA, Del Junco DJ, Powell-Dunford N,, et al. Association of prehospital blood product transfusion during medical evacuation of combat casualties in Afghanistan with acute and 30-day survival. JAMA, 2017 Oct 24;318(16):1581-1591.
3. Giancarelli A, Birrer KL, Alban RF, et al. Hypocalcemia in trauma patients receiving massive transfusion. J Surg Res, 2016 May 1;202(1):182-7. doi: 10.1016/j.jss.2015.12.036. Epub 2015 Dec 30
4. Ho KM, Leonard AD. Concentration-dependent effect of hypocalcaemia on mortality of patients with critical bleeding requiring massive transfusion: a cohort study. Anaesth Intensive Care, 2011 Jan;39(1):46-54.
5. MacKay EJ, Stubna M, Holena D, et al. Abnormal calcium levels during trauma resuscitation are associated with increased mortality, increased blood product use, and greater hospital resource consumption: A pilot investigation. Anesth Analg, Sep 2017. 125(3):895–901.
6. Kyle T, Greaves I, Beynon A. et al. Ionised calcium levels in major trauma patients who received blood en route to a military medical treatment facility. Emerg Med J, Feb 2018;35:176-179.
7. Webster S, Todd S2, Redhead J, Wright C, et al. Ionised calcium levels in major trauma patients who received blood in the Emergency Department. Emerg Med J, 2016 Aug;33(8):569-72. doi: 10.1136/emermed-2015-205096. Epub 2016 Feb 4.
8. Rotondo MF, Schwab CW, McGonigal MD, et al., Damage control: an approach for improved survival in exsanguinating penetrating abdominal injury. J Trauma, 1993. 35(3): p. 375-82; discussion 382-3.
9. Holcomb, JB, Jenkins, D, Rhee, P, et al., Damage control resuscitation: directly addressing the early coagulopathy of trauma. J Trauma, 2007. 62(2): p. 307-10.
10. Bjerkvig CK, Strandenes G, Eliassen HS, et al., "Blood failure" time to view blood as an organ: How oxygen debt contributes to blood failure and its implications for remote damage control resuscitation. Transfusion, 2016. 56 Suppl 2: p. S182-9.
11. Woolley T, Thompson P, Kirkman E, et al. Trauma Hemostasis and Oxygenation Research Network position paper on the role of hypotensive resuscitation as part of remote damage control resuscitation. J Trauma Acute Care Surg, 2018 Jun;84(6S Suppl 1):S3-S13.
12. Balogh Z, McKinley BA, Cocanour CS. Supranormal trauma resuscitation causes more cases of abdominal compartment syndrome. Arch Surg, 2003. 138(6): p. 637-42; discussion 642-3.
13. American College of Surgeons, Advanced Trauma Life Support (ATLS), 10th Edition 2018.
14. Pidcoke HF, Aden JK, Mora AG, et al. Ten-year analysis of transfusion in Operation Iraqi Freedom and Operation Enduring Freedom: Increased plasma and platelet use correlates with improved survival. J Trauma Acute Care Surg, 2012. 73(6 Suppl 5): p. S445-52.
15. Borgman MA, Spinella PC, Perkins JG, et al. The ratio of blood products transfused affects mortality in patients receiving massive transfusions at a combat support hospital. J Trauma, 2007. 63(4): p. 805-13.
16. Holcomb JB, Wade CE, Michalek JE, et al. Increased plasma and platelet to red blood cell ratios improves outcome in 466 massively transfused civilian trauma patients. Ann Surg, 2008. 248(3): p. 447-58.
17. Stinger HK, Spinella PC, Perkins JG, et al. The ratio of fibrinogen to red cells transfused affects survival in casualties receiving massive transfusions at an army combat support hospital. J Trauma, 2008. 64(2 Suppl): p. S79-85; discussion S85.
18. Shaz BH, Dente CJ, Nicholas J, et al. Increased number of coagulation products in relationship to red blood cell products transfused improves mortality in trauma patients. Transfusion, 2010. 50(2): p. 493-500.
19. Holcomb JB, Tilley BC, Baraniuk S, et al. Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: The PROPPR randomized clinical trial. JAMA, 2015. 313(5): p. 471-82.
20. Nascimento B, Callum J, Tien H, et al. Effect of a fixed-ratio (1:1:1) transfusion protocol versus laboratory-results-guided transfusion in patients with severe trauma: a randomized feasibility trial. CMAJ, 2013. 185(12): p. E583-9.
21. Spinella PC, Perkins JG, Grathwohl Kw, et al. Warm fresh whole blood is independently associated with improved survival for patients with combat-related traumatic injuries. J Trauma, 2009. 66(4 Suppl): p. S69-76.
22. Spinella PC, Dunne J, Beilman GJ, et al. Constant challenges and evolution of U.S. military transfusion medicine and blood operations in combat. Transfusion, 2012. 52(5): p. 1146-53.
23. Perkins JG, Cap AP, Spinella PC, et al. Comparison of platelet transfusion as fresh whole blood versus apheresis platelets for massively transfused combat trauma patients. Transfusion, 2011. 51(2): p. 242-52.
24. Fisher AD, Miles EA, Cap AP, et al. Tactical Damage Control Resuscitation. Mil Med, 2015. 180(8): p. 869-75.
25. Strandenes G, Berseus O, Cap AP, et al. Low titer group O whole blood in emergency situations. Shock, 2014. 41 Suppl 1: p. 70-5.
26. Taylor AL, Eastridge BJ. Advances in the use of whole blood in combat trauma resuscitation. Transfusion, 2016. 56: p. 15a-16a.
27. Army Medical Research Laboratory, Armed Services Blood Program Report 1943-1973: Lessons learned applicable to civil disasters and other considerations, 1973.
28. Taylor AL, Eastridge BJ. Advances in the use of whole blood in combat trauma resuscitation. Transfusion, 2016. 56: p. 15a-16a.
29. Pidcoke HF, McFaul SJ, Ramasubramanian AK, et al. Primary hemostatic capacity of whole blood: a comprehensive analysis of pathogen reduction and refrigeration effects over time. Transfusion, 2013. 53 Suppl 1: p. 137S-149S.
30. Strandenes G, Austlid I, Apelseth TO, et al. Coagulation function of stored whole blood is preserved for 14 days in austere conditions: A ROTEM feasibility study during a Norwegian antipiracy mission and comparison to equal ratio reconstituted blood. J Trauma Acute Care Surg, 2015. 78(6 Suppl 1): p. S31-8.
31. Jobes D, Wolfe Y, O'Neill D, et al. Toward a definition of "fresh" whole blood: an in vitro characterization of coagulation properties in refrigerated whole blood for transfusion. Transfusion, 2011. 51(1): p. 43-51.
32. Cotton BA, Podbielski J, Camp E, et al. A randomized controlled pilot trial of modified whole blood versus component therapy in severely injured patients requiring large volume transfusions. Ann Surg, 2013. 258(4): p. 527-32; discussion 532-3.
33. Bahr MP, Yazer MH, Triulzi DJ, et al. Whole blood for the acutely haemorrhaging civilian trauma patient: a novel idea or rediscovery? Transfus Med, 2016.
34. Seheult JN, Triulzi DJ, Alarcon LH, et al. Measurement of haemolysis markers following transfusion of uncrossmatched, low-titer, group O+ whole blood in civilian trauma patients: initial experience at a level 1 trauma centre. Transfus Med, 2016.
35. Yazer MH, Jackson B, Sperry JL, et al. Initial safety and feasibility of cold-stored uncrossmatched whole blood transfusion in civilian trauma patients. J Trauma Acute Care Surg, 2016. 81(1): p. 21-6.
36. Stubbs JR, Zielinski MD, Jenkins D. The state of the science of whole blood: Lessons learned at Mayo Clinic. Transfusion, 2016. 56 Suppl 2: p. S173-81.
37. Zielinski MD, Jenkin DH, Hughes JD, et al. Back to the future: The renaissance of whole-blood transfusions for massively hemorrhaging patients. Surgery, 2014. 155(5): p. 883-6.
38. Alexander JM, Sarode R, McIntire DD, et al. Whole blood in the management of hypovolemia due to obstetric hemorrhage. Obstet Gynecol, 2009. 113(6): p. 1320-6.
39. Jobes DR, Sesok-Pizzini D, Friedman D. Reduced transfusion requirement with use of fresh whole blood in pediatric cardiac surgical procedures. Ann Thorac Surg, 2015. 99(5): p. 1706-11.
40. Manno CS, Hedberg Kw, Kim HC, et al. Comparison of the hemostatic effects of fresh whole blood, stored whole blood, and components after open heart surgery in children. Blood, 1991. 77(5): p. 930-6.
41. Joint Trauma System, Whole Blood Transfusion Clinical Practice Guideline, 15 May 2018.
42. Joint Trauma System, Frozen Deglycerolized Red Blood Cells Clinical Practice Guideline, 11 Jul 2016.
43. Spinella PC, Frazier E, Pidcoke HF, et al. All plasma products are not created equal: Characterizing differences between plasma products. J Trauma Acute Care Surg, 2015. 78(6 Suppl 1): p. S18-25.
44. Matijevic N, Wang Y, Cotton BA, et al. Better hemostatic profiles of never-frozen liquid plasma compared with thawed fresh frozen plasma. J Trauma Acute Care Surg, 2013. 74(1): p. 84-90; discussion 90-1.
45. Pusateri, A.E., Given, M.B., Schreiber, M.A., et al., Dried plasma: state of the science and recent developments. Transfusion, 2016. 56 Suppl 2: p. S128-39.
46. Pidcoke HF, Spinella PC, Borgman MA, et al. Refrigerated platelets for the treatment of acute bleeding: A review of the literature and reexamination of current standards. Shock, 2014. 41 Suppl 1: p. 51-3.
47. Perkins JG, Cap AP, Spinella PC, et al. An evaluation of the impact of apheresis platelets used in the setting of massively transfused trauma patients. J Trauma, 2009. 66(4 Suppl): p. S77-84; discussion S84-5.
48. Cap AP, Spinella PC, Borgman MA, et al. Timing and location of blood product transfusion and outcomes in massively transfused combat casualties. J Trauma Acute Care Surg, 2012. 73(2 Suppl 1): p. S89-94.
49. Reddoch KM, Pidcoke HF, Montgomery RK, et al. Hemostatic function of apheresis platelets stored at 4 degrees C and 22 degrees C. Shock, 2014. 41 Suppl 1: p. 54-61.
50. Nair PM, Pidcoke HF, Cap AP, et al. Effect of cold storage on shear-induced platelet aggregation and clot strength. J Trauma Acute Care Surg, 2014. 77(3 Suppl 2): p. S88-93.
51. Corley JB, Implementation of Cold Stored Platelets for Combat Trauma Resuscitation. Transfusion, 2016. 56: p. 16a-17a.
52. Getz, T.M., Montgomery, R.K., Bynum, J.A., et al. Storage of platelets at 4 degrees C in platelet additive solutions prevents aggregate formation and preserves platelet functional responses. Transfusion, 2016. 56(6): p. 1320-8.
53. Cap AP. Platelet storage: a license to chill! Transfusion, 2016. 56(1): p. 13-6.
54. Collins PW, Solomon C, Sutor K, et al. Theoretical modelling of fibrinogen supplementation with therapeutic plasma, cryoprecipitate, or fibrinogen concentrate. Br J Anaesth, 2014. 113(4): p. 585-95.
55. Schlimp CJ, Schochl H. The role of fibrinogen in trauma-induced coagulopathy. Hamostaseologie, 2014. 34(1): p. 29-39.
56. Schochl H, Schlimp CJ, Maegele M. Tranexamic acid, fibrinogen concentrate, and prothrombin complex concentrate: data to support prehospital use? Shock, 2014. 41 Suppl 1: p. 44-6.
57. Schochl H, Voelckel W, Maegele M, et al. Endogenous thrombin potential following hemostatic therapy with 4-factor prothrombin complex concentrate: A 7-day observational study of trauma patients. Crit Care, 2014. 18(4): p. R147.
58. Blackbourne LH, Baer DG, Eastridge BJ, et al. Military medical revolution: prehospital combat casualty care. J Trauma Acute Care Surg, 2012. 73(6 Suppl 5): p. S372-7.
59. Kragh JF, Jr., Aden JK, Steinbaugh J, et al. Gauze vs XSTAT in wound packing for hemorrhage control. Am J Emerg Med, 2015. 33(7): p. 974-6.
60. Sims K, Montgomery HR, Dituro P, et al. Management of External Hemorrhage in Tactical Combat Casualty Care: The Adjunctive Use of XStat Compressed Hemostatic Sponges: TCCC Guidelines Change 15-03. J Spec Oper Med, 2016. 16(1): p. 19-28.
61. Pezy P, Flaris AN, Prat NJ, et al. Fixed-distance model for balloon placement during fluoroscopy-free resuscitative endovascular balloon occlusion of the aorta in a civilian population. JAMA Surg, 2016.
62. Napolitano LM. Resuscitative endovascular balloon occlusion of the aorta: indications, outcomes, and training. Crit Care Clin, 2017. 33(1): p. 55-70.
63. Sokol KK, Black GE, Shawhan R, et al. Efficacy of a novel fluoroscopy-free endovascular balloon device with pressure release capabilities in the setting of uncontrolled junctional hemorrhage. J Trauma Acute Care Surg, 2016. 80(6): p. 907-14.
64. Brenner M, Inaba K, Aiolfi A, et al. Resuscitative endovascular balloon occlusion of the aorta and resuscitative thoracotomy in select patients with hemorrhagic shock: Early results from the American Association for the Surgery of Trauma’s Aortic Occlusion in Resuscitation for Trauma and Acute Care Surgery Registry. Presented at the American Association for the Surgery of Trauma 76th Annual Meeting, Baltimore, MD, September 2017. https://www.journalacs.org/article/S1072-7515(18)30098-X/fulltext Accessed Apr 2019.
65. Manley JD, Mitchell BJ, DuBose JJ, Rasmussen TE. A modern case series of Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) in an out-of-hospital, combat casualty care setting. J Spec Oper Med, Spring 2017;17(1):1-8.
66. Smith SA, Hilsden R, Beckett A, McAlister VC. The future of resuscitative endovascular balloon occlusion in combat operations. J R Army Med Corps, 2017 Aug 9. DOI: 10.1136/jramc-2017-000788
67. Joint Trauma System, Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) for Hemorrhagic Shock CPG, 06 Jul 2017.
68. Shakur, H., Roberts, I., Bautista, R., et al. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial. Lancet, 2010. 376(9734): p. 23-32.
69. Roberts I, Prieto-Merino D, Manno D. Mechanism of action of tranexamic acid in bleeding trauma patients: an exploratory analysis of data from the CRASH-2 trial. Crit Care, 2014. 18(6): p. 685.
70. Brohi K, Cohen MJ, Ganter MT, Schultz MJ, Levi M, Mackersie RC, Pittet JF. Acute coagulopathy of trauma: hypoperfusion induces systemic anticoagulation and hyperfibrinolysis. J Trauma, 2008;64(5):1211-7.
71. Hess JR, Brohi K, Dutton RP, et al. The coagulopathy of trauma: a review of mechanisms. J Trauma, 2008;65(4):748-54.
72. CRASH-2 collaborators, Roberts I, Shakur H, et al., The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial. Lancet, 2011. 377(9771): p. 1096-101, 1101 e1-2.
73. Howard JT, Stockinger ZT, Cap AP, Bailey JA, Gross KR. Military use of tranexamic acid in combat trauma: Does it matter? J Trauma Acute Care Surg, 2017 Oct;83(4):579-588.
74. Morrison JJ, Dubose JJ, Rasmussen TE. Military Application of Tranexamic Acid in Trauma Emergency Resuscitation (MATTERs) Study. Arch Surg, 2012. 147(2): p. 113-9.
75. Gayet-Ageron A, Prieto-Merino D, Ker K, et al. Effect of treatment delay on the effectiveness and safety of antifibrinolytics in acute severe haemorrhage: A meta-analysis of individual patient-level data from 40138 bleeding patients. Lancet, 2018;391:125–132.
76. Ramirez R, Spinella P, Bochichio G. Tranexamic acid update in trauma. Crit Care Clin, 2017;33:85–99.
77. Joint Trauma System, Damage Control Resuscitation for Prolonged Field Care Clinical Practice Guideline, 01 Oct 2018.
78. Giancarelli A, Birrer KL, Alban RF, et al. Hypocalcemia in trauma patients receiving massive transfusion. J Surg Res, 2016 May 1;202(1):182-7.
79. MacKay EJ, Stubna MD, Holena DN, et al. Abnormal calcium levels during trauma resuscitation are associated with increased mortality, increased blood product use, and greater hospital resource consumption: A pilot investigation. Anesth Analg, 2017 Sep;125(3):895-901.
80. Webster S, Todd S, Redhead J, Wright C. Ionised calcium levels in major trauma patients who received blood in the Emergency Department. Emerg Med J, 2016 Aug;33(8):569-72. doi: 10.1136/emermed-2015-205096. Epub 2016 Feb 4.
81. Boffard KD, Riou B, Warren B, et al. Recombinant factor VIIa as adjunctive therapy for bleeding control in severely injured trauma patients: two parallel randomized, placebo-controlled, double-blind clinical trials. J Trauma, 2005. 59(1): p. 8-15; discussion 15-8.
82. Dutton RP, McCunn M, Hyder M, et al. Factor VIIa for correction of traumatic coagulopathy. J Trauma, 2004. 57(4): p. 709-18; discussion 718-9.
83. Holcomb JB. Use of recombinant activated factor VII to treat the acquired coagulopathy of trauma. J Trauma, 2005. 58(6): p. 1298-303.
84. Holcomb JB, Hoots K, Moore FA. Treatment of an acquired coagulopathy with recombinant activated factor VII in a damage-control patient. Mil Med, 2005. 170(4): p. 287-90.
85. Hauser CJ, Boffard K, Dutton R, et al. Results of the CONTROL trial: efficacy and safety of recombinant activated Factor VII in the management of refractory traumatic hemorrhage. J Trauma, 2010. 69(3): p. 489-500.
86. Schreiber MA, Perkins JG, Kiraly L, et al. Early predictors of massive transfusion in combat casualties. J Am Coll Surg, 2007. 205(4): p. 541-5.
87. Ogura T, Nakamura Y, Nakano M, et al. Predicting the need for massive transfusion in trauma patients: the Traumatic Bleeding Severity Score. J Trauma Acute Care Surg, 2014. 76(5): p. 1243-50.
88. Moore FA, Nelson T, McKinley Ba, et al. Massive transfusion in trauma patients: tissue hemoglobin oxygen saturation predicts poor outcome. J Trauma, 2008. 64(4): p. 1010-23.
89. Brown JB, Lerner BE, Sperry JL, et al. Prehospital lactate improves accuracy of prehospital criteria for designating trauma activation level. J Trauma Acute Care Surg, 2016. 81(3): p. 445-52.
90. Brohi K, Cohen MJ, Ganter Mt, et al. Acute coagulopathy of trauma: hypoperfusion induces systemic anticoagulation and hyperfibrinolysis. J Trauma, 2008. 64(5): p. 1211-7; discussion 1217.
91. Leemann H, Lustenberger T, Talving P, et al. The role of rotation thromboelastometry in early prediction of massive transfusion. J Trauma, 2010. 69(6): p. 1403-8; discussion 1408-9.
92. Doran CM, Woolley T, Midwinter MJ. Feasibility of using rotational thromboelastometry to assess coagulation status of combat casualties in a deployed setting. J Trauma, 2010. 69 Suppl 1: p. S40-8.
93. Solvik UO, Roraas TH, Petersen PH, et al. Effect of coagulation factors on discrepancies in International Normalized Ratio results between instruments. Clin Chem Lab Med, 2012. 50(9): p. 1611-20.
94. Kim SJ, Lee EY, Park R, et al. Comparison of prothrombin time derived from CoaguChek XS and laboratory test according to fibrinogen level. J Clin Lab Anal, 2015. 29(1): p. 28-31.
95. Duchesne JC, Barbeau JM, Islam TM, et al. Damage control resuscitation: from emergency department to the operating room. Am Surg, 2011. 77(2): p. 201-6.
96. Strandvik GF. Hypertonic saline in critical care: A review of the literature and guidelines for use in hypotensive states and raised intracranial pressure. Anaesthesia, 2009. 64(9): p. 990-1003.
97. Joint Trauma System, Neurosurgery and Severe Head Injury CPG, 02 Mar 2017.
98. Joint Trauma System, Hypothermia Prevention, Monitoring and Management CPG, 20 Sep 2012.
99. Percival TJ, Rasmussen TE. Reperfusion strategies in the management of extremity vascular injury with ischaemia. Br J Surg, 2012. 99 Suppl 1: p. 66-74.