Pralidoxime (2-PAM) Drip Protocol

*given after 1800mg IM Injection (3 ATNAAs) if symptoms persist.

  1. Reconstitute 1 gram 2-PAM with 20mL of sterile water
  2. Add 10mL 2Pam (500mg) to 100 mL Bag of NS and infuse over 5 minutes
  3. Prepare continuous infusion by mixing 1 gram (20mL reconstituted) in 100mL bag of NS which will provide a 10mg/mL solution. Can also prepare 10 grams in 1L NS for a 10mg/mL solution.
  4. Begin continuous infusion at 10mg/kg/hr.