The typical antipsychotic haloperidol (Haldol®) and the atypical antipsychotic quetiapine (Seroquel®) are commonly used for the treatment of delirium. Quetiapine can also be used as an anxiolytic; it is particularly effective when used QHS PRN to help regulate sleep in a patient at risk for anxiety and delirium. Both of these drugs may be associated with prolongation of the QT interval potentially resulting in fatal arrhythmias secondary to torsades des pointes. If these drugs are used, the QTc interval should be monitored with an electrocardiogram (EKG) on a daily basis. They should be discontinued if the QTc exceeds 500 msec or the interval increases 60 msec from baseline.4