(Morb Mortal Wkly Rep. 2018; 67(No. RR-1) [:1-31.])

Abbreviations: HCP – Healthcare Personnel; HBsAg – Hepatitis B surface antigen; anti-HBs – antibody to Hepatitis B surface antigen; HBIG – Hepatitis B immune globulin.

* HBIG should be administered intramuscularly as soon as possible after exposure when indicated. The effectiveness of HBIG when administered ›7 days after percutaneous, mucosal, or nonintact skin exposures is unknown. HBIG dosage is 0.06 mL/kg.

† Should be performed 1-2 months after the last dose of the Hep B vaccine series (and 4-6 months after administration of HBIG to avoid detection of passively administered anti-HBs) using a quantitative method that allows detection of the protective concentration of anti-HBs (≥10 mIU/mL)

- A responder is defined as a person with anti-HBs ≥10 mIU/mL after ≥3 doses of HepB vaccine.

ƪ A nonresponder is defined as a person with anti-HBs ‹10 mIU/mL after ≥6 doses of HepB vaccine.