Disclaimer:  This appendix may or may not discuss investigational, unapproved, or off-label use of drugs or devices. It is based upon the best information available at the time of publication. Patients and physicians are advised to consult prescribing information for products discussed in this appendix. The information provided in this appendix is not meant to substitute for the independent clinical judgment of a physician, relative to diagnostic or treatment options for a specific patient’s medical condition. It is designed to provide information and assist decision making. It is not intended to define a standard of care and should not be construed as one; neither should it be interpreted as prescribing an exclusive course of management. This appendix was developed by experts in this field. Variations in practice will inevitably and appropriately occur when clinicians consider the needs of individual patients, available resources, and limitations unique to an institution or type of practice. Every healthcare professional making use of this appendix is responsible for evaluating the appropriateness of applying it in the setting of any clinical situation. This appendix does not supersede any DoD policy.